Potassium Phosphate, Tribasic → 3-(6-Chloropyrazin-2-yl)pyrazolo[1,5-a]pyridine

Participants

Reaction Steps

2,6-Dichloropyrazine (0.316 g, 2.12 mmol), tris(dibenzylideneacetone)dipalladium (0), (0.097 g, 0.106 mmol), tricyclohexylphosphine (0.06 g, 0.212 mmol) and potassium phosphate (1.35 g, 6.36 mmol) were added to a suspension of 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazolo[1,5-a]pyridine (Preparation 27a, 0.518 g, 2.12 mmol)) in N,N′-dimethylformamide (10 mL). This mixture was subjected to microwave irradiation at 100° C. for 40 min. The reaction mixture was filtered through Celite®, eluting with methanol, and the filtrate was evaporated. The resulting residue was purified by flash chromatography (2:8 to 3:7 ethyl acetate/hexane) to yield the title compound (0.162 g, 33%, two steps) as a pale yellow solid.

Provenance & Evidence