HCID 67370966, compound → HCID 67373117, compound

Participants

Reaction Steps

10% Palladium on carbon (0.392 g, 0.37 mmol) was added to a suspension of 5-nitro-2-(pyrazolo[1,5-a]pyrazin-3-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrimidin-4-amine (Preparation 25, 0.785 g, 2.31 mmol) in ethanol (50 mL) and the mixture was stirred under an hydrogen atmosphere at ambient temperature. After 4 hours, the mixture was filtered through Celite® and the filter cake was washed with ethanol. The combined filtrate and washings were evaporated to give the title compound (0.670 g, 94%) as a pale green solid.

Provenance & Evidence