HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Methyl-2-nitroanisole → 2-Methoxy-p-toluidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Methyl-2-nitroanisole | HCID 97455 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Methoxy-p-toluidine | HCID 170219 | 99.7% |
Reaction Steps
A mixture of 5-methyl-2-nitroanisol (265 g, 1.58 mol) and 10% Pd/C (39.75 g) in THF (1.32 L) was stirred overnight at rt under 1 atm of hydrogen. Filtration over kieselguhr and evaporation afforded 216.1 g of the crude product which was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09206184B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-c5d7bf044e5e4070a2c5ebc7b10d6d61 |
| Source note | uspto-grants-2015_12 |