5-Chloro-2-(chloromethyl)-1-[3-(methylsulfonyl)propyl]-1H-benzimidazole → 5-Chloro-1-[3-(methylsulfonyl)propyl]-2-{[3-(methylsulfonyl)-1H-pyrrolo[2,3-c]pyridin-1-yl]methyl}-1H-benzimidazole

HRID 1500846Notes

Reaction equation

HRID 1500846 reaction equation
[CH3:1][S:2]([C:5]1[C:13]2[C:8](=[CH:9][N:10]=[CH:11][CH:12]=2)[NH:7][CH:6]=1)(=[O:4])=[O:3].[Cl:14][C:15]1[CH:32]=[CH:31][C:18]2[N:19]([CH2:24][CH2:25][CH2:26][S:27]([CH3:30])(=[O:29])=[O:28])[C:20]([CH2:22]Cl)=[N:21][C:17]=2[CH:16]=1>>[Cl:14][C:15]1[CH:32]=[CH:31][C:18]2[N:19]([CH2:24][CH2:25][CH2:26][S:27]([CH3:30])(=[O:28])=[O:29])[C:20]([CH2:22][N:7]3[C:8]4=[CH:9][N:10]=[CH:11][CH:12]=[C:13]4[C:5]([S:2]([CH3:1])(=[O:3])=[O:4])=[CH:6]3)=[N:21][C:17]=2[CH:16]=1

Participants

3

Reactant 2

HCID 618081805-Chloro-2-(chloromethyl)-1-[3-(methylsulfonyl)propyl]-1H-benzimidazole2×HCID 899243263-(methylsulfonyl)-1H-pyrrolo[2,3-c]pyridine

Product 1

HCID 729499745-Chloro-1-[3-(methylsulfonyl)propyl]-2-{[3-(methylsulfonyl)-1H-pyrrolo[2,3-c]pyridin-1-yl]methyl}-1H-benzimidazole

Procedure

The title compound was prepared in analogy to Example 1-2 by using 3-(methylsulfonyl)-1H-pyrrolo[2,3-c]pyridine and 5-chloro-2-(chloromethyl)-1-(3-(methylsulfonyl)propyl)-1H-benzo[d]imidazole instead of 3-(methylsulfonyl)-1H-indole and 5-chloro-2-(chloromethyl)-1-(3-(methylsulfonyl)propyl)-1H-benzo[d]imidazole.

Sources & evidence

ORD record
ord-fc8cc2737068466b87368467f3c314fe
Source dataset
uspto-grants-2015_12
Patent number
US09206191B2

Reaction notes

Loading…