5-Chloro-2-(chloromethyl)-1-[3-(methylsulfonyl)propyl]-1H-benzimidazole → 1-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-benzimidazol-2-yl}methyl)-3-(methylsulfonyl)-1H-indazole

HRID 1500852Notes

Reaction equation

HRID 1500852 reaction equation
[CH3:1][S:2]([C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7][N:6]=1)(=[O:4])=[O:3].[Cl:14][C:15]1[CH:32]=[CH:31][C:18]2[N:19]([CH2:24][CH2:25][CH2:26][S:27]([CH3:30])(=[O:29])=[O:28])[C:20]([CH2:22]Cl)=[N:21][C:17]=2[CH:16]=1>>[Cl:14][C:15]1[CH:32]=[CH:31][C:18]2[N:19]([CH2:24][CH2:25][CH2:26][S:27]([CH3:30])(=[O:28])=[O:29])[C:20]([CH2:22][N:7]3[C:8]4[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=4)[C:5]([S:2]([CH3:1])(=[O:3])=[O:4])=[N:6]3)=[N:21][C:17]=2[CH:16]=1

Participants

3

Reactant 2

HCID 618081805-Chloro-2-(chloromethyl)-1-[3-(methylsulfonyl)propyl]-1H-benzimidazole2×HCID 1785048563-methanesulfonyl-1H-indazole

Product 1

HCID 729501431-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-benzimidazol-2-yl}methyl)-3-(methylsulfonyl)-1H-indazole

Procedure

Example 1-8 was prepared in analogy to Example 1-2 by using above 3-(methylsulfonyl)-1H-indazole and 5-chloro-2-(chloromethyl)-1-(3-(methylsulfonyl)propyl)-1H-benzo[d]imidazole instead of 3-(methylsulfonyl)-1H-indol e and 5-chloro-2-(chloromethyl)-1-(3-(methylsulfonyl)propyl)-1H-benzo[d]imidazole.

Workup

  1. customExample 1-8 was prepared in analogy to Example 1-2

Sources & evidence

ORD record
ord-30901e66508e4f40b22656c97d6392fb
Source dataset
uspto-grants-2015_12
Patent number
US09206191B2

Reaction notes

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