HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl (4-chloro-2-nitrophenyl)carbamate → 5-Chloro-2-chloromethyl-1-(2-methanesulfonyl-ethyl)-1H-benzoimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl (4-chloro-2-nitrophenyl)carbamate | HCID 53980145 | — |
| Reactant | 5-Chloro-2-(chloromethyl)-1-[3-(methylsulfonyl)propyl]-1H-benzimidazole | HCID 61808180 | — |
| Reactant | 3-methanesulfonyl-1H-indole | HCID 86767790 | — |
| Product | 5-Chloro-2-chloromethyl-1-(2-methanesulfonyl-ethyl)-1H-benzoimidazole | HCID 54935133 | — |
Reaction Steps
5-Chloro-2-chloromethyl-1-(2-methanesulfonyl-ethyl)-1H-benzoimidazole was prepared in analogy to Example 1-2 by using (4-chloro-2-nitro-phenyl)-carbamic acid tert-butyl ester as starting material instead of 3-(methylsulfonyl)-1H-indole and 5-chloro-2-(chloromethyl)-1-(3-(methylsulfonyl)propyl)-1H-benzo[d]imidazole. MS obsd. (ESI+) [(M+H)+] 308.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09206191B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-677e7ffdf04c44e39ae96641fd5400eb |
| Source note | uspto-grants-2015_12 |