5-Chloro-2-chloromethyl-1-(2-methanesulfonyl-ethyl)-1H-benzoimidazole → 1-({5-chloro-1-[2-(methylsulfonyl)ethyl]-1H-benzimidazol-2-yl}methyl)-3-(methylsulfonyl)-1H-indazole

HRID 1500857Notes

Reaction equation

HRID 1500857 reaction equation
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]2[N:6]([CH2:11][CH2:12][S:13]([CH3:16])(=[O:15])=[O:14])[C:7]([CH2:9]Cl)=[N:8][C:4]=2[CH:3]=1.[CH3:19][S:20]([C:23]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[NH:25][N:24]=1)(=[O:22])=[O:21].CS(C1C2C(=CC=CC=2)NC=1)(=O)=O>>[Cl:1][C:2]1[CH:18]=[CH:17][C:5]2[N:6]([CH2:11][CH2:12][S:13]([CH3:16])(=[O:15])=[O:14])[C:7]([CH2:9][N:25]3[C:26]4[C:31](=[CH:30][CH:29]=[CH:28][CH:27]=4)[C:23]([S:20]([CH3:19])(=[O:21])=[O:22])=[N:24]3)=[N:8][C:4]=2[CH:3]=1

Participants

4

Reactant 3

HCID 549351335-Chloro-2-chloromethyl-1-(2-methanesulfonyl-ethyl)-1H-benzoimidazoleHCID 867677903-methanesulfonyl-1H-indoleHCID 1785048563-methanesulfonyl-1H-indazole

Product 1

HCID 729503051-({5-chloro-1-[2-(methylsulfonyl)ethyl]-1H-benzimidazol-2-yl}methyl)-3-(methylsulfonyl)-1H-indazole

Procedure

Example 1-12 was prepared in analogy to Example 1-2 by using 5-chloro-2-(chloromethyl)-1-(2-(methylsulfonyl)ethyl)-1H-benzo[d]-imidazole and 3-(methylsulfonyl)-1H-indazole instead of 5-chloro-2-(chloromethyl)-1-(3-(methylsulfonyl)propyl)-1H-benzo[d]imidazole and 3-(methylsulfonyl)-1H-indole.

Workup

  1. customExample 1-12 was prepared in analogy to Example 1-2

Sources & evidence

ORD record
ord-b4fe2c81f5564a95a6a24dd97897865c
Source dataset
uspto-grants-2015_12
Patent number
US09206191B2

Reaction notes

Loading…