5-Chloro-2-chloromethyl-1-(2-methanesulfonyl-ethyl)-1H-benzoimidazole → 1-({5-Chloro-1-[2-(methylsulfonyl)ethyl]-1H-benzimidazol-2-yl}methyl)-3-(propan-2-ylsulfonyl)-1H-indazole

HRID 1500858Notes

Reaction equation

HRID 1500858 reaction equation
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]2[N:6]([CH2:11][CH2:12][S:13]([CH3:16])(=[O:15])=[O:14])[C:7]([CH2:9]Cl)=[N:8][C:4]=2[CH:3]=1.[CH:19]([S:22]([C:25]1[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[NH:27][N:26]=1)(=[O:24])=[O:23])([CH3:21])[CH3:20]>>[Cl:1][C:2]1[CH:18]=[CH:17][C:5]2[N:6]([CH2:11][CH2:12][S:13]([CH3:16])(=[O:15])=[O:14])[C:7]([CH2:9][N:27]3[C:28]4[C:33](=[CH:32][CH:31]=[CH:30][CH:29]=4)[C:25]([S:22]([CH:19]([CH3:21])[CH3:20])(=[O:23])=[O:24])=[N:26]3)=[N:8][C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 549351335-Chloro-2-chloromethyl-1-(2-methanesulfonyl-ethyl)-1H-benzoimidazoleHCID 178461016HCID 178461016, compound2×

Product 1

HCID 729503061-({5-Chloro-1-[2-(methylsulfonyl)ethyl]-1H-benzimidazol-2-yl}methyl)-3-(propan-2-ylsulfonyl)-1H-indazole

Procedure

The title compound was prepared in analogy to Example 1-9 by using 5-chloro-2-(chloromethyl)-1-(2-(methylsulfonyl)ethyl)-1H-benzo[d]imidazole and 3-(isopropylsulfonyl)-1H-indazole instead of 5-chloro-2-(chloromethyl)-1-(3-(methylsulfonyl)propyl)-1H-benzo[d]imidazole and 3-(isopropylsulfonyl)-1H-indazole.

Sources & evidence

ORD record
ord-3e91c4aaba7940aca5e5604919ccc300
Source dataset
uspto-grants-2015_12
Patent number
US09206191B2

Reaction notes

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