5-Chloro-2-(chloromethyl)-1-(tetrahydro-1,1-dioxido-3-thienyl)-1H-benzimidazole → 1-{[5-Chloro-1-(1,1-dioxidotetrahydrothiophen-3-yl)-1H-benzimidazol-2-yl]methyl}-3-(methylsulfonyl)-1H-indazole

HRID 1500863Notes

Reaction equation

HRID 1500863 reaction equation
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]2[N:6]([CH:11]3[CH2:15][CH2:14][S:13](=[O:17])(=[O:16])[CH2:12]3)[C:7]([CH2:9]Cl)=[N:8][C:4]=2[CH:3]=1.C(S([N:25]1[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH:27]=[N:26]1)(=O)=O)C.[CH3:34][S:35](C1C2C(=CN=CC=2)NN=1)(=[O:37])=[O:36]>>[Cl:1][C:2]1[CH:19]=[CH:18][C:5]2[N:6]([CH:11]3[CH2:15][CH2:14][S:13](=[O:17])(=[O:16])[CH2:12]3)[C:7]([CH2:9][N:25]3[C:33]4[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=4)[C:27]([S:35]([CH3:34])(=[O:37])=[O:36])=[N:26]3)=[N:8][C:4]=2[CH:3]=1

Participants

4

Reactant 3

HCID 436596405-Chloro-2-(chloromethyl)-1-(tetrahydro-1,1-dioxido-3-thienyl)-1H-benzimidazoleHCID 118114501ethanesulfonyl-1H-indazoleHCID 178504858HCID 178504858, compound

Product 1

HCID 729503071-{[5-Chloro-1-(1,1-dioxidotetrahydrothiophen-3-yl)-1H-benzimidazol-2-yl]methyl}-3-(methylsulfonyl)-1H-indazole

Procedure

The title compound was prepared in analogy to Example 2-1 by using 5-chloro-2-chloromethyl-1-(1,1-dioxo-tetrahydro-1λ6-thiophen-3-yl)-1H-benzoimidazole and 3-M ethanesulfonyl-1H-indazole instead of 5-chloro-2-chloromethyl-1-((S)-1,1-dioxo-tetrahydro-1λ6-thiophen-3-yl)-1H-benzoimidazole and 3-(methylsulfonyl)-1H-pyrazolo[3,4-c]pyridine.

Sources & evidence

ORD record
ord-8b37e33569ef4cec91935eb6f9fb57b6
Source dataset
uspto-grants-2015_12
Patent number
US09206191B2

Reaction notes

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