5-chloro-2-chloromethyl-1-oxetan-3-yl-1H-benzoimidazole → 1-{[5-Chloro-1-(oxetan-3-yl)-1H-benzimidazol-2-yl]methyl}-3-(methylsulfonyl)-1H-indazole

HRID 1500864Notes

Reaction equation

HRID 1500864 reaction equation
[Cl:1][C:2]1[CH:16]=[CH:15][C:5]2[N:6]([CH:11]3[CH2:14][O:13][CH2:12]3)[C:7]([CH2:9]Cl)=[N:8][C:4]=2[CH:3]=1.[CH3:17][S:18]([C:21]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[NH:23][N:22]=1)(=[O:20])=[O:19].CS(C1C2C(=CN=CC=2)NN=1)(=O)=O>>[Cl:1][C:2]1[CH:16]=[CH:15][C:5]2[N:6]([CH:11]3[CH2:14][O:13][CH2:12]3)[C:7]([CH2:9][N:23]3[C:24]4[C:29](=[CH:28][CH:27]=[CH:26][CH:25]=4)[C:21]([S:18]([CH3:17])(=[O:19])=[O:20])=[N:22]3)=[N:8][C:4]=2[CH:3]=1

Participants

4

Reactant 3

HCID 899244165-chloro-2-chloromethyl-1-oxetan-3-yl-1H-benzoimidazoleHCID 1785048563-methanesulfonyl-1H-indazoleHCID 178504858HCID 178504858, compound

Product 1

HCID 729503091-{[5-Chloro-1-(oxetan-3-yl)-1H-benzimidazol-2-yl]methyl}-3-(methylsulfonyl)-1H-indazole

Procedure

The title compound was prepared in analogy to Example 2-1 by using 5-chloro-2-chloromethyl-1-oxetan-3-yl-1H-benzoimidazole and 3-methanesulfonyl-1H-indazole instead of 5-chloro-2-chloromethyl-1-((S)-1,1-dioxo-tetrahydro-1λ6-thiophen-3-yl)-1H-benzoimidazole and 3-(methylsulfonyl)-1H-pyrazolo[3,4-c]pyridine.

Sources & evidence

ORD record
ord-a7de31a5bcff4e9eb8b5b6788bac0103
Source dataset
uspto-grants-2015_12
Patent number
US09206191B2

Reaction notes

Loading…