HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium → 4,4,4-Trifluoro-3-hydroxybutanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium | HCID 223 | — |
| Reactant | Ethyl 4,4,4-trifluoro-3-hydroxybutanoate | HCID 136210 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4,4,4-Trifluoro-3-hydroxybutanamide | HCID 45075650 | 87.6% |
Reaction Steps
A solution of ethyl 4,4,4-trifluoro-3-hydroxybutanoate (3.0 g, 16.1 mmol) in MeOH (8 mL) was stirred with aqueous ammonium (16 mL) at room temperature overnight. The mixture was concentrated to afford 4,4,4-trifluoro-3-hydroxybutanamide (2.19 g, yield: 87.6%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09206191B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-4395146190b04bbdafff1a3588795775 |
| Source note | uspto-grants-2015_12 |