Sodium chloroacetate → HCID 89923839, compound

HRID 1500907Notes

Reaction equation

HRID 1500907 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH2:16])[C:5]([NH:9][CH2:10][CH2:11][C:12]([F:15])([F:14])[F:13])=[C:6]([F:8])[CH:7]=1.[Cl:17][CH2:18][C:19]([O-])=O.[Na+].CS(C1C2C(=CN=CC=2)NN=1)(=O)=O>>[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]2[N:9]([CH2:10][CH2:11][C:12]([F:13])([F:14])[F:15])[C:19]([CH2:18][Cl:17])=[N:16][C:4]=2[CH:3]=1

Participants

4

Reactant 3

HCID 23665759Sodium chloroacetateHCID 89923979HCID 89923979, compoundHCID 178504858HCID 178504858, compound

Product 1

HCID 89923839HCID 89923839, compound

Procedure

5-Chloro-2-chloromethyl-7-fluoro-1-(3,3,3-trifluoro-propyl)-1H-benzoimidazole was prepared according to the procedure described in Example 2-1 by using 4-chloro-6-fluoro-N-(3,3,3-trifluoropropyl)benzene-1,2-diamine and sodium 2-chloroacetate instead of 5-chloro-2-chloromethyl-1-((S)-1,1-dioxo-tetrahydro-1λ6-thiophen-3-yl)-1H-benzoimidazole and 3-(methylsulfonyl)-1H-pyrazolo[3,4-c]pyridine. MS obsd. (ESI+) [(M+H)+] 315.

Sources & evidence

ORD record
ord-ec0b889de8284b87b4ec6f077903d227
Source dataset
uspto-grants-2015_12
Patent number
US09206191B2

Reaction notes

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