HCID 22933768, compound → HCID 72948352, compound

HRID 1500908Notes

Reaction equation

HRID 1500908 reaction equation
[Cl:1][C:2]1[CH:18]=[C:17]([F:19])[C:5]2[N:6]([CH2:11][CH2:12][C:13]([F:16])([F:15])[F:14])[C:7]([CH2:9]Cl)=[N:8][C:4]=2[CH:3]=1.[CH3:20][S:21]([C:24]1[C:32]2[C:27](=[CH:28][N:29]=[CH:30][CH:31]=2)[NH:26][N:25]=1)(=[O:23])=[O:22].CS(N1C2C(=CC=CC=2)C=N1)(=O)=O>>[Cl:1][C:2]1[CH:18]=[C:17]([F:19])[C:5]2[N:6]([CH2:11][CH2:12][C:13]([F:16])([F:15])[F:14])[C:7]([CH2:9][N:26]3[C:27]4=[CH:28][N:29]=[CH:30][CH:31]=[C:32]4[C:24]([S:21]([CH3:20])(=[O:22])=[O:23])=[N:25]3)=[N:8][C:4]=2[CH:3]=1

Participants

4

Reactant 3

HCID 22933768HCID 22933768, compoundHCID 89923839HCID 89923839, compoundHCID 178504858HCID 178504858, compound

Product 1

HCID 72948352HCID 72948352, compound

Procedure

Example 5-1 was prepared in analogy to Example 4-1 by using 5-chloro-2-(chloromethyl)-7-fluoro-1-(3,3,3-trifluoropropyl)-1H-benzo[d]imidazole and 3-(methylsulfonyl)-1H-pyrazolo[3,4-c]pyridine instead of 5-chloro-2-chloromethyl-1-(4,4,4-trifluoro-butyl)-1H-benzoimidazole and methanesulfonyl-1H-indazole.

Workup

  1. customExample 5-1 was prepared in analogy to Example 4-1

Sources & evidence

ORD record
ord-383f0a82f2ad4e4f9628ebc3e19a8ea7
Source dataset
uspto-grants-2015_12
Patent number
US09206191B2

Reaction notes

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