Propionic Acid → HCID 72949449, compound

HRID 1500911Notes

Reaction equation

HRID 1500911 reaction equation
[Cl:1][C:2]1[CH:29]=[CH:28][C:5]2[N:6]([C@@H:23]3[CH2:27][CH2:26][NH:25][CH2:24]3)[C:7]([CH2:9][N:10]3[C:18]4[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=4)[C:12]([S:19]([CH3:22])(=[O:21])=[O:20])=[N:11]3)=[N:8][C:4]=2[CH:3]=1.[C:30](O)(=[O:33])[CH2:31][CH3:32].C(OC(=O)C)(=O)C>>[Cl:1][C:2]1[CH:29]=[CH:28][C:5]2[N:6]([C@@H:23]3[CH2:27][CH2:26][N:25]([C:30](=[O:33])[CH2:31][CH3:32])[CH2:24]3)[C:7]([CH2:9][N:10]3[C:18]4[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=4)[C:12]([S:19]([CH3:22])(=[O:21])=[O:20])=[N:11]3)=[N:8][C:4]=2[CH:3]=1

Participants

4

Reactant 3

HCID 1032Propionic AcidHCID 7918Acetic AnhydrideHCID 118114319HCID 118114319, compound

Product 1

HCID 72949449HCID 72949449, compound

Procedure

The title compound was prepared in analogy to Example 2-17 by using 1-({5-chloro-1-[(3R)-(pyrrolidin-3-yl)]-1H-benzo[d]imidazol-2-yl}methyl)-3-(methylsulfonyl)-1H-indazole and propionic acid instead of 1-{[5-chloro-1-(pyrrolidin-3-yl)-1H-benzo[d]imidazol-2-yl]methyl}-3-(methylsulfonyl)-1H-pyrazolo[3,4-c]pyridine and acetic anhydride.

Sources & evidence

ORD record
ord-612eacdff25c41eda45d5f6cb8575a29
Source dataset
uspto-grants-2015_12
Patent number
US09206191B2

Reaction notes

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