Ammonia → HCID 82131111, compound

HRID 1500917Notes

Reaction equation

HRID 1500917 reaction equation
[CH3:1][O:2][C:3]1[CH:19]=[CH:18][C:6]([CH2:7][N:8]2[C:12](=[O:13])[CH2:11][CH:10]([C:14](OC)=[O:15])[CH2:9]2)=[CH:5][CH:4]=1.[NH3:20]>>[CH3:1][O:2][C:3]1[CH:19]=[CH:18][C:6]([CH2:7][N:8]2[C:12](=[O:13])[CH2:11][CH:10]([C:14]([NH2:20])=[O:15])[CH2:9]2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 4093874Methyl 1-(4-methoxybenzyl)-5-oxopyrrolidine-3-carboxylate

Product 1

HCID 82131111HCID 82131111, compoundYield 96.5%

Procedure

A mixture of methyl 1-(4-methoxybenzyl)-5-oxopyrrolidine-3-carboxylate (65.8 g, 250 mmol) and aqueous ammonia (1.5 L) was stirred at room temperature overnight. The resulting reaction mixture was filtered. The filter cake was washed with H2O several times and dried in vacuo to afford 1-(4-methoxy-benzyl)-5-oxo-pyrrolidine-3-carboxylic acid amide as a white solid (60.0 g, yield: 96.5%).

Workup

  1. customThe resulting reaction mixture
  2. filtrationwas filtered
  3. washThe filter cake was washed with H2O several times
  4. customdried in vacuo

Sources & evidence

ORD record
ord-efc06be2a143441eafa7f431fc4c1fbc
Source dataset
uspto-grants-2015_12
Patent number
US09206191B2

Reaction notes

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