HCID 89924214, compound → HCID 89923945, compound

HRID 1500920Notes

Reaction equation

HRID 1500920 reaction equation
ClC1C=C(N)C(N[C@H]2CCS(=O)(=O)C2)=CC=1.[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([NH:24][CH:25]2[CH2:29][N:28]([CH2:30][C:31]3[CH:36]=[CH:35][C:34]([O:37][CH3:38])=[CH:33][CH:32]=3)[C:27](=[O:39])[CH2:26]2)=[C:20]([N+:40]([O-])=O)[CH:19]=1>>[NH2:40][C:20]1[CH:19]=[C:18]([Cl:17])[CH:23]=[CH:22][C:21]=1[NH:24][CH:25]1[CH2:29][N:28]([CH2:30][C:31]2[CH:36]=[CH:35][C:34]([O:37][CH3:38])=[CH:33][CH:32]=2)[C:27](=[O:39])[CH2:26]1

Participants

3

Reactant 2

HCID 89924214HCID 89924214, compoundHCID 89933257HCID 89933257, compound

Product 1

HCID 89923945HCID 89923945, compound

Procedure

4-[(2-Amino-4-chlorophenyl)amino]-1-(4-methoxybenzyl)pyrrolidin-2-one was prepared in analogy to 4-chloro-N—((S)-1,1-dioxo-tetrahydro-1λ6-thiophen-3-yl)-benzene-1,2-diamine in Example 2-1 by using 4-[(4-chloro-2-nitrophenyl)amino]-1-(4-methoxybenzyl)pyrrolidin-2-one instead of (4-chloro-2-nitro-phenyl)-((S)-1,1-dioxo-tetrahydro-1λ6-thiophen-3-yl)-amine.

Sources & evidence

ORD record
ord-e8b5a7c03d814a568ebe174fa022cdcf
Source dataset
uspto-grants-2015_12
Patent number
US09206191B2

Reaction notes

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