2-Oxa-5-azaspiro[3.4]octane-5-carboxylic acid, 7-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester → tert-butyl 7-amino-2-oxa-5-azaspiro[3.4]octane-5-carboxylate

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Reaction Steps

A solution of tert-butyl 7-{[(benzyloxy)carbonyl]amino}-2-oxa-5-azaspiro[3.4]octane-5-carboxylate (566 mg, 1.56 mmol) in 20 mL of MeOH was stirred with 10% Pd/C (100 mg) under hydrogen atmosphere at room temperature for 50 minutes. The resulting mixture was filtered and the filtration was concentrated in vacuo to afford tert-butyl 7-amino-2-oxa-5-azaspiro[3.4]octane-5-carboxylate (343 mg, yield: 96.3%) as light viscous oil.

Provenance & Evidence