Potassium Carbonate → HCID 89581114, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 2-hydroxyisonicotinate (306 mg, 2 mmol) in N,N-dimethylformamide (30 mL) was added (1-bromoethyl)benzene (0.37 g, 2 mmol) and potassium carbonate (0.55 g, 4 mmol). The mixture was heated to 110° C. and stirred at the same temperature for 12 hours. The solvent was evaporated in vacuum and the residue was purified by preparative-HPLC to give methyl 2-oxo-1-(1-phenylethyl)-1,2-dihydropyridine-4-carboxylate (90 mg, 17%) The product was used directly in the next step.

Provenance & Evidence