Hydrochloric Acid → HCID 89585074, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl 2-oxo-1-(1-phenylethyl)-1,2-dihydropyridine-4-carboxylate (90 mg, 0.35 mmol), lithium hydroxide monohydrate (57.1 mg, 1.36 mmol), tetrahydrofuran (5 mL), methanol (1 mL) and water (1 mL) was stirred at 20° C. for 4 hours. The mixture was neutralized to pH=1 with concentrated hydrochloric acid and then extracted with acetic ether (15 mL×3). The combined organic phase was dried by sodium sulfate, then filtered. The filtrate was concentrated in vacuum to give 2-oxo-1-(1-phenylethyl)-1,2-dihydropyridine-4-carboxylic acid as a white solid (60 mg, 70%). LRMS (M+H)− m/z: cald. 243.09. found 243.

Provenance & Evidence