Sodium Carbonate → HCID 178425204, compound

Participants

Reaction Conditions

Reaction Steps

4-(2-Bromophenoxy)-3-chloro-N-((2-hydroxy-4,6-dimethylpyridin-3-yl)methyl)benzamide (90 mg, 0.2 mmol), pyridin-4-ylboronic acid (48 mg, 0.4 mmol), tetrakis(triphenylphosphine)palladium (45 mg, 0.04 mmol), sodium carbonate (62 mg, 0.6 mmol), dioxane (8 mL) and water (2 mL) were added to a flask. The mixture was stirred at 90° C. for 12 hours under nitrogen atmosphere. The resultant mixture was concentrated to give a residue. The residue was purified by column chromatography (silica gel, dichloromethane/methanol=20:1) to give 3-chloro-N-((2-hydroxy-4,6-dimethylpyridin-3-yl)methyl)-4-(2-(pyridin-4-yl)phenoxy)benzamide as a light yellow solid (30 mg, 32%). LRMS (M+H+) m/z: calcd 459.13. found 459. HPLC purity (214 nm): 98%. 1H NMR (300 MHz, d6-DMSO): δ 11.46 (s, 1H), 8.57 (d, J=6.3 Hz, 2H), 8.40 (t, J=4.5 Hz, 1H), 8.02 (d, J=1.8 Hz, 1H), 7.73 (dd, J=8.7 Hz, J=2.1 Hz, 1H), 7.62-7.46 (m, 4H), 7.36 (t, J=6.3 Hz, 1H), 7.16 (d, J=2.1 Hz, 1H), 6.78 (d, J=6.3 Hz, 1H), 5.84 (s, 1H), 4.24 (d, J=4.5 Hz, 2H), 2.15 (s, 3H), 2.10 (s, 3H).

Provenance & Evidence