Methylparaben → Methyl 4-(benzyloxy)benzoate

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 4-hydroxybenzoate (1.37 g, 9 mmol) and (bromomethyl)benzene (1.71 g, 10 mmol) in acetonitrile (100 mL) was added potassium carbonate (2.76 g, 18.8 mmol). The reaction mixture was stirred at 60° C. for 2 hours. After the reaction, the solvent was removed under reduced pressure to give the crude product which was purified by column chromatography (silica gel, dichloromethane/methanol=100:1) to give the pure product (2.18 g, 99%). LRMS (M+H+) m/z: calcd 243.09. found 243.

Provenance & Evidence