Methanol → (R)-1-(4-Bromophenyl)ethanol

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-bromoacetophenone (5.0 g, 25 mmol) and (S)-2-Methyl-CBS-oxazaborolidine (1.25 mL, 1 M) in anhydrous dichloromethane (80 mL) was added borane-methyl sulfide complex (2.1 g, 27 mmol) over 1 hour at −20° C. After addition completed, the mixture was stirred at −20° C. for 2 hours, then stirred at room temperature for 12 hours. After the reaction, methanol (20 mL) was added, and stirred for 0.5 hour. Then the mixture was diluted with water (100 mL) and the organic phase was dried over anhydrous sodium sulfate. The mixture was filtered and the filtrate was concentrated. The residue was purified by column chromatography (silica gel, ethyl acetate/petroleum ether=1:8) to give pure product (R)-1-(4-bromophenyl)ethanol as a white solid (4.6 g, 92%).

Provenance & Evidence