Lithium Hydroxide → 4-((Methyl(phenyl)amino)methyl)benzoic acid

Participants

Reaction Steps

To a solution of methyl 4-((methyl(phenyl)amino)methyl)benzoate (400 mg, 1.57 mmol) in tetrahydrofuran (30 mL) and methanol (10 mL) was added lithium hydroxide (210 mg, 5 mmol) in water (10 mL). The mixture was stirred at room temperature for 2 hours. The suspension was concentrated in vacuo and acidified with concentrated hydrochloric acid (12 N, 5 mL). The mixture was re-dissolved by water (50 mL) and dichloromethane (50 mL). Organic phase was separated and concentrated to give the product 4-((methyl(phenyl)amino)methyl)benzoic acid (200 mg, 53%) as a white solid.

Provenance & Evidence