Phenol → 1-Bromo-4-(2-methyl-1-phenoxypropyl)benzene

Participants

Reaction Conditions

Reaction Steps

Azodicarboxylic acid diisopropyl ester (824 mg, 4.1 mmol) was added to the mixture of 1-(4-bromophenyl)-2-methylpropan-1-ol (620 mg, 2.7 mmol), phenol (307 mg, 3.2 mmol), triphenylphosphine (1.07 g, 4.1 mmol) and tetrahydrofuran (15 mL) at 20° C. Then the mixture was stirred at 20° C. for 12 hours. The resultant mixture was washed with water (20 mL×2). The organic phase was separated, dried over sodium sulfate, filtered and concentrated to give a residue. The residue was purified by column chromatography (silica gel, petroleum ether/ethyl acetate=10:1) to gave 1-bromo-4-(2-methyl-1-phenoxypropyl)benzene as a colorless oil (353 g, 44%). 1H NMR (300 MHz, CDCl3): δ 8.07-7.98 (m, 2H), 7.56-7.48 (m, 2H), 7.32-7.28 (m, 2H), 6.84-6.77 (m, 3H), 4.49 (d, J=6.6 Hz, 1H), 2.35-2.30 (m, 1H), 1.01 (d, J=6.6 Hz, 6H).

Provenance & Evidence