Methanol → HCID 89580898, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl 4-(2-methyl-1-phenoxypropyl)benzoate (240 mg, 0.84 mmol), lithium hydroxide monohydrate (178 mg, 4.2 mmol), tetrahydrofuran (12 mL), methanol (4 mL) and water (4 mL) was stirred at 20° C. for 4 hours. The reaction mixture was concentrated, acidified with concentrated hydrochloric acid to pH=1, extracted with ethyl acetate (20 mL×3). The organic phase was separated, dried over sodium sulfate, filtered and concentrated to give a residue. The residue was purified by column chromatography (silica gel, petroleum ether/ethyl acetate=2:1) to give 4-(2-methyl-1-phenoxypropyl)benzoic acid as a white solid (227 mg, 100%). LRMS (M+H)− m/z: calcd 268.15. found 268.

Provenance & Evidence