Lithium hydroxide, monohydrate → HCID 89582819, compound

Participants

Reaction Steps

To a solution of methyl 1-phenoxy-2,3-dihydro-1H-indene-5-carboxylate (400 mg, 1.49 mmol) in tetrahydrofuran, methanol and water (3:1:1, 20 mL) was added lithium hydroxide monohydrate (377 mg, 8.98 mmol). The mixture was stirred at room temperature for 2 hours. The mixture was concentrated in vacuo and quenched with hydrochloric acid aqueous (1N, 15 mL). Then the mixture was concentrated to give 1-phenoxy-2,3-dihydro-1H-indene-5-carboxylic acid (350 mg, 92%) as white solid. LRMS (M+H)− m/z: calcd 254.09. found 254.

Provenance & Evidence