1-Hydroxybenzotriazole → HCID 178425177, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-(1-(4-fluorophenoxy)ethyl)benzoic acid (260 mg, 1 mmol), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (382 mg, 2 mmol), N-hydroxybenzotriazole (270 mg, 2 mmol), triethylamine (0.3 mL) and dichloromethane (15 mL) were stirred at 25° C. for half an hour. Then 3-(aminomethyl)-4,6-dimethylpyridin-2-ol (152 mg, 1 mmol) was added. The mixture was stirred at 25° C. for 12 hours. To the mixture, water (20 mL) was added and the mixture was extracted with dichloromethane (30 mL×3). The combined organic phase was dried by sodium sulfate and then filtered. The filtrate was concentrated in vacuo. The residue was purified by column chromatography (silica gel, dichloromethane/methanol=20:1) to give 4-(1-(4-fluorophenoxy)ethyl)-N-((2-hydroxy-4,6-dimethylpyridin-3-yl)methyl)benzamide (Compound I-46) (115 mg, 29%). LRMS (M+H+) m/z: calcd 394.17. found 394. HPLC purity (214 nm): 94%. 1H NMR (300 MHz, d6-DMSO): δ 11.44 (s, 1H), 8.30 (t, J=5.1 Hz, 1H), 7.77 (d, J=8.4 Hz, 2H), 7.41 (d, J=8.4 Hz, 2H), 7.04-6.85 (m, 4H), 5.83 (s, 1H), 5.47 (q, J=6.6 Hz, 1H), 4.26 (d, J=5.1 Hz, 2H), 2.16 (s, 3H), 2.10 (s, 3H), 1.52 (d, J=6.6 Hz, 3H).

Provenance & Evidence