Hydrochloric Acid → HCID 56998584, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl 4-(3-methyl-1-phenoxybutyl)benzoate (25 mg, 0.084 mmol), lithium hydroxide monohydrate (42 mg, 1 mmol), tetrahydrofuran (6 mL), methanol (2 mL) and water (2 mL) was stirred at 20° C. for 4 hours. The mixture was acidified to pH=1 with concentrated hydrochloric acid and then extracted with dichloromethane (10 mL×3). The combined organic phase was dried by sodium sulfate and filtered. The filtrate was concentrated in vacuo to give 4-(3-methyl-1-phenoxybutyl)benzoic acid (24 mg, 99%).

Provenance & Evidence