反应详情

To a solution of tert-butyl 4-(benzofuran-2-yl)benzoate (0.3 g, 1.0 mmol) in methanol (20 mL) was added raney nickel (0.20 g). The reaction mixture was stirred at room temperature for 2 hours under hydrogen (4 atm). After the reaction, the mixture was filtered and the filtrate was concentrated. The residue was purified by column chromatography (silica gel, ethyl acetate/petroleum ether=1:20) to give pure product tert-butyl 4-(2,3-dihydrobenzofuran-2-yl)benzoate as a white solid (0.03 g, 10%).

1. customAfter the reaction
2. filtrationthe mixture was filtered
3. concentrationthe filtrate was concentrated
4. customThe residue was purified by column chromatography (silica gel, ethyl acetate/petroleum ether=1:20)