Methanol → HCID 89581450, compound

Participants

Reaction Steps

Lithium hydroxide hydrate (0.04 g, 1.0 mmol) was added to a solution of methyl 5-phenoxy-5,6,7,8-tetrahydronaphthalene-2-carboxylate (0.04 g, 0.14 mmol) in a mixed solution of tetrahydrofuran (6.0 mL), methanol (2 mL) and water (2 mL). The reaction mixture was stirred at room temperature for 1 hour. After the reaction, the solvent was removed in vacuo. Hydrochloric acid aqueous (3 mol/L) was added to make pH 3-5, and the mixture was extracted with dichloromethane. The combined organic phase was washed with water (20 mL×3), dried over anhydrous sodium sulfate. The mixture was filtered and the filtrate was concentrated to dryness to give pure product 5-phenoxy-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid as a white solid (0.032 g, 86%).

Provenance & Evidence