Triethylamine → HCID 178425141, compound

Participants

Reaction Steps

To a solution of 5-phenoxy-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid (0.032 g, 0.12 mmol), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (0.06 g, 0.3 mmol) and N-hydroxybenzotriazole (0.03 g, 0.22 mmol) in dichloromethane (10 mL) was added triethylamine (0.03 g, 0.3 mmol). The reaction mixture was stirred for 15 minutes at room temperature, then 3-(aminomethyl)-4,6-dimethylpyridin-2-ol (0.03 g, 0.2 mmol) was added. The reaction mixture was stirred at room temperature for 12 hours. After the reaction, the mixture was washed with water (10 mL×3). The organic phase was concentrated and the residue was purified by column chromatography (silica gel, dichloromethane/methanol=15:1) to give pure product N-((2-hydroxy-4,6-dimethylpyridin-3-yl)methyl)-5-phenoxy-5,6,7,8-tetrahydronaphthalene-2-carboxamide (Compound I-52) as a white solid (0.031 g, 63%). LRMS (M+H+) m/z: calcd 402.19. found 402. 1H NMR (300 MHz, CD3OD): δ 7.59 (s, 1H), 7.57 (d, J=7.5 Hz, 1H), 7.37 (d, J=7.8 Hz, 1H), 7.28 (t, J=7.2 Hz, 2H), 7.02-6.92 (m, 3H), 6.10 (s, 1H), 5.43 (t, J=4.5 Hz, 1H), 4.48 (s, 2H), 2.90-2.82 (m, 2H), 2.37 (s, 3H), 2.24 (s, 3H), 2.08-1.83 (m, 4H).

Provenance & Evidence