Sodium borohydride → HCID 11437583, compound

Participants

Reaction Steps

Sodium borohydride (1.04 g, 27.4 mmol) was added to the solution of tert-butyl 4-benzoylbenzoate (1.54 g, 5.46 mmol) in ethanol (50 mL). Then the mixture was stirred at room temperature for 2 hours. The resultant mixture was concentrated to give a residue. The residue was purified by column chromatography (silica gel, petroleum ether/ethyl acetate=3:1) to give tert-butyl 4-(hydroxy(phenyl)methyl)benzoate (1.55 g, 100%). 1H NMR (300 MHz, d6-DMSO): δ 7.82 (d, J=8.1 Hz, 2H), 7.48 (d, J=8.1 Hz, 2H), 7.36-7.26 (m, 4H), 7.22-7.17 (m, 1H), 6.04 (d, J=3.9 Hz, 1H), 5.76 (d, J=3.9 Hz, 1H), 1.52 (s, 9H).

Provenance & Evidence