Hydrochloric Acid → HCID 89580793, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl 4-(1-phenoxyethyl)benzoate (0.32 g, 1.2 mmol), lithium hydroxide monohydrate (571 mg, 13.6 mmol), tetrahydrofuran (15 mL), methanol (5 mL) and water (5 mL) was stirred at 20° C. for 4 hours. The mixture was neutralized to pH=1 with concentrated hydrochloric acid and then extracted with ethyl acetate (15 mL×3). The combined organic phase was dried by sodium sulfate, and then filtered. The filtrate was concentrated in vacuo to give 3-methyl-4-(phenoxymethyl)benzoic acid (0.21 g, 72%).

Provenance & Evidence