反应详情

To a solution of 1-bromo-4-(1-bromoethyl)benzene (200 mg, 0.76 mmol) and pyridin-2-ol (87 mg, 0.91 mmol) in N,N-dimethylformamide (30 mL) was added cesium carbonate (496 mg, 1.52 mmol). The mixture was stirred at room temperature for 12 hours. And then solvent was removed to give a residue. The residue was purified by column chromatography (silica gel, ethyl acetate/petroleum ether=1:10) to give 1-(1-(4-bromophenyl)ethyl)pyridin-2(1H)-one (161 mg, 76%) LRMS (M+H+) m/z: calcd 277.0. found 277.

1. customAnd then solvent was removed
2. customto give a residue
3. customThe residue was purified by column chromatography (silica gel, ethyl acetate/petroleum ether=1:10)