Hydrochloric Acid → HCID 89585090, compound

Participants

Reaction Steps

To a mixed solution of methanol (10 mL) and water (2 mL), methyl 4-(1-(2-oxopyridin-1(2H)-yl)ethyl)benzoate (145 mg, 0.56 mmol) and lithium hydroxide hydrate (40 mg, 0.95 mmol) were added. The reaction mixture was stirred at room temperature for 12 hours. Then the mixture was acidified by hydrogen chloride aqueous solution (1N) to pH=6 and extracted with dichloromethane (20 mL×3). The organic phase was concentrated to give 4-(1-(2-oxopyridin-1(2H)-yl)ethyl)benzoic acid (111 mg, 81%).

Provenance & Evidence