Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | 2,6-dimethyl-4-oxo-1H-pyrimidine-5-carbonitrile | HCID 178432753 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 178432754 | HCID 178432754 | 19% |
Reaction Steps
A mixture of 4-hydroxy-2,6-dimethylpyrimidine-5-carbonitrile (2.7 g, 18.1 mmol), lithium aluminium hydride (2.1 g, 54.3 mmol), and tetrahydrofuran (80 mL) was stirred at 25° C. for 4 hours. Water (5 mL) was added to the mixture. The mixture was concentrated to give a residue. The residue was purified by column chromatography (silica gel, dichloromethane/methanol=10:1) to give 5-(aminomethyl)-2,6-dimethylpyrimidin-4-ol as a white solid (525 mg, 19%). LRMS (M+H+) m/z: calcd 153.09. found 153.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09206128B2 |
|---|
| Source dataset | uspto-grants-2015_12 |
|---|
| ORD ID | ord-c7968c26707b45c68a7b67f36b2afc8b |
|---|
| Source note | uspto-grants-2015_12 |
|---|
