2-Chloropyridine → HCID 89581271, compound

Participants

Reaction Steps

A solution of 1-(4-bromophenyl)ethanol (2.0 g, 10.0 mmol), 2-chloropyridine (1237 mg, 11.0 mmol), potassium hydroxide (1839 mg, 32.8 mmol) and 18-crown-6 (132 mg, 0.5 mmol) in toluene (40 mL) was stirred at reflux for 3 hrs. The mixture was concentrated to give a residue. The residue was purified by column chromatography (silica gel, petroleum ethe/ethyl acetate=20:1) to give 2-(1-(4-bromophenyl)ethoxy)pyridine as a white solid (2.6 g, 94%). LRMS (M+H+) m/z: calcd 277.01. found 277.

Provenance & Evidence