Hydrochloric Acid → HCID 89580617, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl 3-methyl-4-(1-phenoxyethyl)benzoate (0.12 g, 0.44 mmol), lithium hydroxide monohydrate (285 mg, 6.8 mmol), tetrahydrofuran (15 mL), methanol (5 mL) and water (5 mL) was stirred at 20° C. for 4 hours. The mixture was neutralized to pH=1 with concentrated hydrochloric acid and then extracted with ethyl acetate (15 mL×3). The combined organic phase was dried by sodium sulfate, and then filtered. The filtrate was concentrated in vacuo to give 3-methyl-4-(1-phenoxyethyl)benzoic acid (95 mg, 84%).

Provenance & Evidence