Lithium Hydroxide → HCID 118562724, compound

Participants

Reaction Steps

Lithium hydroxide (2 g, 83.3 mmol) was added to a solution of (S)-methyl 4-(1-(3-bromophenoxy)ethyl)benzoate (1.8 g, 5.4 mmol) in methanol (100 mL) and water (10 mL). The reaction mixture was stirred at room temperature for 3 hours. After the reaction, the solvent was removed in vacuo. 3 mol/L hydrogen chloride (aq) was added to make pH 2-3, and the product was extracted with dichloromethane. The combined organic phase was washed with Sodium Chloride (aq) (20 mL×3), dried over anhydrous sodium sulfate, and the solvent was evaporated to dryness to give (S)-4-(1-(3-bromophenoxy)ethyl)benzoic acid (1.7 g, 98%).

Provenance & Evidence