Sodium hydride → HCID 89581270, compound

Participants

Reaction Conditions

Reaction Steps

NaH (300 mg, 60%, 7.5 mmol) was suspended in N,N-dimethylformamide. 1-(4-bromophenyl)ethanol was added to the above mixture and stirred at 40° C. for 0.5 hour. Then 2-chloropyrimidine was added to the above mixture and stirred at 100° C. for 12 hours. The mixture was concentrated to give a residue. The residue was purified by column chromatography (silica gel, petroleum ethe/ethyl acetate=3:1) to give 2-(1-(4-bromophenyl)ethoxy)pyrimidine as a white solid (2.6 g, 94%). LRMS (M+H+) m/z: calcd 278.01. found 278.

Provenance & Evidence