Hydrochloric Acid → HCID 89580975, compound

Participants

Reaction Steps

To a mixed solution of methanol (10 mL) and water (2 mL), methyl 4-(1-(pyridin-4-yloxy)ethyl)benzoate (151 mg, 0.59 mmol) and lithium hydroxide were added. The mixture was stirred at room temperature for 12 hours. Then the reaction mixture was acidified by hydrogen chloride aqueous solution (1N) to adjust pH=6, and then extracted with dichloromethane (20 mL×3). And the mixture was concentrated to give 4-(1-(pyridin-4-yloxy)ethyl)benzoic acid (127 mg, 88%).

Provenance & Evidence