Hydrochloric Acid → HCID 89581348, compound

Participants

Reaction Steps

To the solution of methyl 4-(1-(cyclohexyloxy)ethyl)benzoate (60 mg, 0.23 mmol) in methanol and water (50 mL/10 mL) was added lithium hydroxide (100 mg, 4.2 mmol), the solution was stirred at room temperature for 12 hours. Then the solution was acidified by hydrogen chloride (1 N/mol) pH to 6, extracted with dichloromethane (80 mL*3), evaporated the solvent to give 4-(1-(cyclohexyl oxy)ethyl)benzoic acid (47 mg 82%).

Provenance & Evidence