Sodium Carbonate → HCID 178425190, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (S)-4-(1-(3-bromophenoxy)ethyl)-N-((2-hydroxy-4,6-dimethylpyridin-3-yl)methyl)benzamide (0.20 g, 0.44 mmol), 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine (0.13 g, 0.59 mmol), tetrakis(triphenylphosphine) palladium(0) (0.05 g, 0.04 mmol) in 1,4-dioxane (10 mL) and water (1.0 mL) was added sodium carbonate (0.14 g, 1.0 mmol). The reaction mixture was stirred at 90° C. for 12 hours. After the reaction, the reaction mixture was poured to the water (100 mL) and the product was extracted by dichloromethane (100 mL), concentrated and purified by column chromatography (silica gel:dichloromethane:methanol=12:1 with 1% ammonia aqueous solution) to give pure product (S)-4-(1-(3-(2-aminopyrimidin-5-yl)phenoxy)ethyl)-N-((2-hydroxy-4,6-dimethylpyridin-3-yl)methyl)benzamide (0.12 g, 60%) as a white solid. LR MS (M+H+): calcd for: 469.21. found 469.

Provenance & Evidence