HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 2-Methyl-4-(1-phenylethyl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl 2-methyl-4-(1-phenylethyl)benzoate | HCID 89581013 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Methyl-4-(1-phenylethyl)benzoic acid | HCID 89581437 | 90% |
Reaction Steps
To a solution of tert-butyl 2-methyl-4-(1-phenylethyl)benzoate (1.6 g, 5.4 mmol) in dichloromethane 9 mL, and 3 mL trifluoroacetic acid was added. The mixture was stirred 0.5 hour. Thin layer chromatography showed full conversion. The reaction mixture was concentrated to give 2-methyl-4-(1-phenylethyl)benzoic acid (1 g, 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09206128B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-2bac5739529f421fbe22be87e77d5b43 |
| Source note | uspto-grants-2015_12 |