Lithium Hydroxide → HCID 89581389, compound

Participants

Reaction Steps

To a solution of methyl 3-fluoro-4-(1-phenoxyethyl)benzoate (400 mg, 1.5 mmol) in mixed solution of tetrahydrofuran/methanol/water=3:1:1 (4 mL) was added lithium hydroxide (200 mg, 8.4 mmol). The mixture was stirred at room temperature for 2 hours. The suspension was concentrated in vacuo and quenched with hydrochloride acid aqueous (1N, 5 mL). To the residue, water (50 mL) was added and extracted with dichloromethane (2*50 mL). The combined organic phase was separated, dried over sodium sulfate, filtered and concentrated to give a residue. The residue was purified by column chromatography (silica gel, petroleum ether/ethyl acetate=5:1) to give 3-fluoro-4-(1-phenoxyethyl)benzoic acid as pale solid (300 mg, 82%).

Provenance & Evidence