Triethylamine → HCID 178425230, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (R)-2-oxo-1-(1-phenylethyl)-1,2-dihydropyridine-4-carboxylic acid (336 mg, 1.4 mmol), 1-hydroxybenzotriozole (373 mg, 2.8 mmol), 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (531 mg, 2.8 mmol), triethylamine (1.0 mL) in dichloromethane (30 mL) was added 3-(aminomethyl)-4,6-dimethylpyridin-2-ol (210 mg, 1.4 mmol). The reaction mixture was stirred at 0° C. for 13 hours. The mixture was washed with water (20 mL×2). The organic phase was dried over sodium sulfate and filtered. The filtrate was concentrated. The residue was purified by column chromatography (silica gel, dichloromethane/methanol=10:1) to give (R)—N-((2-hydroxy-4,6-dimethylpyridin-3-yl)methyl)-2-oxo-1-(1-phenylethyl)-1,2-dihydropyridine-4-carboxamide as a white solid (360 mg, 68%). LRMS (M+H+) m/z: calcd 377.17. found 377. HPLC Purity (214 nm): 100%. 1H NMR (300 MHz, d6-DMSO): δ 11.44 (s, 1H), 8.53 (t, J=4.8 Hz, 1H), 7.66 (d, J=3.3 Hz, 1H), 7.38-7.26 (m, 5H), 6.78 (s, 1H), 6.51 (dd, J=1.8 Hz, J2=6.9 Hz, 1H), 6.13 (q, J=7.2 Hz, 1H), 5.84 (s, 1H), 4.22 (d, J=4.8 Hz, 2H), 2.13 (s, 3H), 2.10 (s, 3H), 1.68 (d, J=7.2 Hz, 3H).

Provenance & Evidence