Lithium Hydroxide → HCID 89580924, compound

Participants

Reaction Steps

To a solution of Lithium hydroxide (420 mg, 10.2 mmol) in tetrahydrofuran, menthol and water (20 mL, 3:1:1, V/V) was added methyl 2-fluoro-4-(1-phenoxyethyl)benzoate (600 mg, 2.42 mmol). The reaction mixture was stirred at room temperature for 1 h. The mixture was quench with 10% hydrochloric acid (aqueous), extracted with dichloromethane and menthol (30 mL, 10:1), the combine organic layer was dried with anhydrous sodium sulfate, filtered and evaporated to give product 2-fluoro-4-(1-phenoxyethyl)benzoic acid (450 mg, 82%). LCMS (M+H+) m/z: calcd 260.08. found 260.

Provenance & Evidence