Hydrochloric Acid → HCID 89580720, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl 4-(1-(4-cyanophenoxy)ethyl)benzoate (370 mg, 1.3 mmol), lithium hydroxide monohydrate (571 mg, 13.6 mmol), tetrahydrofuran (45 mL), methanol (15 mL) and water (15 mL) was stirred at 20° C. for 4 hours. The mixture was neutralized to pH=1 with concentrated hydrochloric acid and then extracted with ethyl acetate (55 mL×3). The combined organic phase was dried by sodium sulfate, then filtered. The filtrate was evaporated in vacuo to give 4-(1-(4-cyanophenoxy)ethyl)benzoic acid (310 mg, 74%) as a white solid. LRMS (M+H+) m/z: cald 267.09. found 267.

Provenance & Evidence