Triethylamine → HCID 178425200, compound

Participants

Reaction Steps

A solution of 4-(3-cyanophenoxy)benzoic acid (40 mg, 0.17 mmol) in dichloromethane (20 mL) was added 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (48 mg, 0.25 mmol), N-hydroxy benzotriazole (34 mg, 0.25 mmol) and triethylamine (34 mg, 0.33 mmol), stirred for 30 min. Then 3-(aminomethyl)-4,6-dimethylpyridin-2-ol (26 mg, 0.17 mmol) was added and the mixture was stirred at room temperature for 12 hours. The mixture was washed with water (50 mL), dried over sodium sulfate, concentrated. The residue was purified by column chromatography (silica gel, dichloromethane/methanol=20:1) to give 3-(3-cyanophenoxy)-N-((2-hydroxy-4,6-dimethylpyridin-3-yl)methyl)benzamide (21 mg, 58%)

Provenance & Evidence