Lithium Hydroxide → HCID 89580475, compound

Participants

Reaction Steps

To a solution of methyl 4-(1-(pyrimidin-4-yloxy)ethyl)benzoate (0.26 g, 1 mmol) in methanol (5 mL) and tetrahydrofuran (15 mL) was added lithium hydroxide (120 mg, 5 mmol) in water (5 mL), then stirred at room temperature for 5 hours. The reaction mixture was concentrated, the residue was acidified with 6 N hydrochloric acid, by filtration the solid was collected to give-4-(1-(pyrimidin-4-yloxy)ethyl)benzoic acid (0.19 g, 78% yield). LRMS (M+H+) m/z: calcd for 244.08. found 244.

Provenance & Evidence